Treatment of murine cutaneous melanoma with near infrared light

Photochem Photobiol. 2002 Mar;75(3):296-301. doi: 10.1562/0031-8655(2002)075<0296:tomcmw>2.0.co;2.

Abstract

Treatment of cutaneous melanoma (M-3 and B16-F10 implanted in mice) with rapidly-scanned, tightly-focused near infrared light elicits selective destruction of tumor tissue. A single laser treatment yielded complete eradication in >90% of B16-F10 tumors with thicknesses of approximately 3 mm; amelanotic M-3 tumors proved less responsive (ca 25% clearance rate). In addition to local tumor destruction, laser treatment of B16-F10 tumors in immunocompetent mice stimulated enhanced cytokine levels (interleukin-2 and interleukin-10) within treated tumor tissues and rejection of tumor cells upon a subsequent challenge dose. Such an antitumor immune response may lead to improved outcomes at both the treatment site and at sites of distant metastasis.

MeSH terms

  • Animals
  • Female
  • Infrared Rays*
  • Melanoma, Experimental / immunology
  • Melanoma, Experimental / pathology
  • Melanoma, Experimental / radiotherapy*
  • Mice
  • Mice, Inbred C57BL
  • Mice, Nude
  • Skin Neoplasms / immunology
  • Skin Neoplasms / pathology
  • Skin Neoplasms / radiotherapy*